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A Three-Way Train Wreck on P450IID6

Hi! I'm AnneRose Blayk…

Have you ever wondered what the DeathWorld is like?

This is but one of the many thrilling insights you may experience on an involuntary trip on mCPP!

A brief explanation of the "Executive Summary" below: mCPP is a potent anxiety-inducing drug (and a weak hallucinogen) that is the primary byproduct of Trazodone, a drug in common use as a sleeping aid. Prozac strongly interferes with the clearing of mCPP from the body... and moreover, some people have a poor ability to eliminate mCPP from their system to start with, due to their genetic endowment (including me!). Put all these together... and you may just get a train wreck. I certainly did!

I experienced the symptoms listed in the light blue and pink boxes...

A 3-Way Train Wreck on P450IID6 (PDF)

Side Effects Experienced on Prozac (JPG)

Side Effects Experienced on Trazodone (JPG)

Just in case you think I was "making shit up years after the fact"...

I documented these side effects and provided this documentation, linked below, to all of the concerned legal actors along with my health care providers back in April 1997, because I wanted to know what had gone wrong.

"Medical History and Recent Physical and Psychological Symptomatology, 4/28/97" - Kevin Eric Saunders a/k/a bonze blayk

Here are the documents I shared with everyone concerned with my "care and treatment" back in 2000 with citations of scientific research supporting my contentions regarding the effects of Prozac and Trazodone in my case... and the hallucinogenic properties of mCPP:

KES/bb summary of abstracts on mCPP 5/22/00 (PDF - 23 pages)

KES/bb summary of abstracts on CYP2D6, Prozac, Trazodone, mCPP 5/24/00 (PDF - 21 pages)

"Is mCPP really an hallucinogen?"

fuck yeah!

"Trazodone, meta-chlorophenylpiperazine (an hallucinogenic drug and trazodone metabolite), and the hallucinogen trifluoromethylphenylpiperazine cross-react
with the EMIT-II ecstasy immunoassay in urine."

Logan BK, Costantino AG, Rieders EF, Sanders D.
Journal of Analytic Toxicology 2010 Nov;34(9):587-9.

"For sure?"


"Expert peer review on pre-review report: 1-(3-chlorophenyl)piperazine (mCPP)",

35th Expert Committee on Drug Dependence, Hammamet, Tunisia — June 4-8, 2012
World Health Organization.

mCPP has psychostimulant, anxiety-provoking and hallucinogenic effects. The effects are noted 45-90 minutes after oral administration and include euphoria, illusions (colour enhancement), circum-oral paraesthesia, and in higher doses overt hallucinosis equivalent to primary hallucinogens such as lysergic acid diethylamide (LSD).

"Do you have a metabolic defect caused by GENETICS?"


Trazodone generates m-CPP: in 2008 risks from m-CPP might outweigh benefits of trazodone.
R. E. Kast. World Journal of Biological Psychiatry 2009;10(4 Pt 2):682-5.

"This commentary argues that the documented potential for harm and multiple risks of m-CPP outweigh potential benefits of trazodone..."

Are we done with trazodone? The potential for damage by m-CPP - a metabolite of trazodone.
R. E. Kast. Acta Neuropsychiatrica Volume 19, Issue 3, pages 220-221, June 2007.

Folks with defective CYP2D6*4 alleles (such as myself!) love to smoke cannabis...
Genetic Polymorphism Of Cytochrome P450 2D6 * 4 In Cannabis Smokers
M. A. Sohayla, Z. E. Ayman & E. Ayman. The Internet Journal of Toxicology. 2008 Vol 5 No 1.

"Murple" relates a very unpleasant experience with 50mg of Trazodone, courtesy of the Erowid Vaults: "I can't believe that something which turns to mCPP in the body is sold as an unscheduled prescription drug!!!" (Erowid Added: Dec 29, 2003)

I took 275mg of Trazodone over 7 days, on top of 20mg/day Prozac and a defective CYP2D6/P450IID6 metabolism! Yippee!

And it was my first exposure ever to a synthetic hallucinogen...

Consequences... and Truth:

My Medwatch report to the FDA, submitted on 12/30/2002.

AnneRose Blayk - SURVIVOR

A timely release by RUSH was a consolation

… and I'd never seen this video until sometime around 2010!
Yet - how apropos the whole affair!

Lee, Lifeson, & Peart

Driven up and down in circles
Skidding down a road of black ice
Staring in and out storm windows
Driven to a fool's paradise


Driven to the margin of error
Driven to the edge of control
Driven to the margin of terror
Driven to the edge of a deep, dark hole

Driven day and night in circles
Spinning like a whirlwind of leaves
Stealing in and out back alleys
Driven to another den of thieves


Driven in -- Driven to the edge
Driven out -- On the thin end of the wedge
Driven off -- By things I've never seen
Driven on -- By the road to somewhere I've never been


The road unwinds towards me
What was there is gone
The road unwinds before me
And I go riding on

My New Year's Resolution for 2011...
I will see a warning label placed on Trazodone.

- AnneRose Blayk

(F/K/A "Kevin Eric Saunders a/k/a bonze blayk")

AnneRose Blayk



Updated 11/6/10, 1/7/11, 2/1/11, 6/30/11, 10/2/11, 3/20/12,
11/26/12, 4/30/13, 1/2/15, 5/18/18